TY - JOUR
T1 - A panoramic view of cell population dynamics in mammalian aging
AU - Zhang, Zehao
AU - Schaefer, Chloe
AU - Jiang, Weirong
AU - Lu, Ziyu
AU - Lee, Jasper
AU - Sziraki, Andras
AU - Abdulraouf, Abdulraouf
AU - Wick, Brittney
AU - Haeussler, Maximilian
AU - Li, Zhuoyan
AU - Molla, Gesmira
AU - Satija, Rahul
AU - Zhou, Wei
AU - Cao, Junyue
N1 - Publisher Copyright:
© 2025 American Association for the Advancement of Science. All rights reserved.
PY - 2025/1/17
Y1 - 2025/1/17
N2 - To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.
AB - To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=85216036213&partnerID=8YFLogxK
U2 - 10.1126/science.adn3949
DO - 10.1126/science.adn3949
M3 - Article
C2 - 39607904
AN - SCOPUS:85216036213
SN - 2096-5672
VL - 387
JO - Journal of Bio-X Research
JF - Journal of Bio-X Research
IS - 6731
M1 - eadn3949
ER -