A Penetrating Look at Stochasticity in Development

Robert J. Johnston, Claude Desplan

Research output: Contribution to journalShort surveypeer-review


In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.

Original languageEnglish (US)
Pages (from-to)610-612
Number of pages3
Issue number5
StatePublished - Mar 5 2010

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'A Penetrating Look at Stochasticity in Development'. Together they form a unique fingerprint.

Cite this