A Penetrating Look at Stochasticity in Development

Robert J. Johnston; Claude Desplan

doi:10.1016/j.cell.2010.02.018

A Penetrating Look at Stochasticity in Development

Research output: Contribution to journal › Short survey › peer-review

Abstract

In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.

Original language	English (US)
Pages (from-to)	610-612
Number of pages	3
Journal	Cell
Volume	140
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2010.02.018
State	Published - Mar 5 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2010.02.018

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title = "A Penetrating Look at Stochasticity in Development",

abstract = "In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.",

author = "Johnston, {Robert J.} and Claude Desplan",

note = "Funding Information: C.D. is supported by NIH R01 EY013010. R.J.J. was supported by a Jane Coffin Childs Memorial Fund fellowship.",

year = "2010",

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AU - Johnston, Robert J.

AU - Desplan, Claude

N1 - Funding Information: C.D. is supported by NIH R01 EY013010. R.J.J. was supported by a Jane Coffin Childs Memorial Fund fellowship.

PY - 2010/3/5

Y1 - 2010/3/5

N2 - In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.

AB - In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.

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VL - 140

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JO - Cell

JF - Cell

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A Penetrating Look at Stochasticity in Development

Abstract

ASJC Scopus subject areas

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