@article{37d6d58683a94f26aed0fe8a64cb8d37,
title = "A Philosophical Perspective on Evolutionary Systems Biology",
abstract = "Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB{\textquoteright}s progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.",
keywords = "Evolutionary biology, Evolutionary systems biology, Explanation, Philosophy of biology, Philosophy of science, Systems biology",
author = "O{\textquoteright}Malley, {Maureen A.} and Soyer, {Orkun S.} and Siegal, {Mark L.}",
note = "Funding Information: Melinda Fagan, Olaf Wolkenhauer, and Michael Lynch made helpful comments on an earlier draft of this paper. Arno Steinacher kindly drew the images. We thank the KLI for funding and hosting this meeting in Konrad Lorenz{\textquoteright}s summer mansion in Altenberg, near Vienna. Eva Lackner, Isabella Sarto-Jackson, Werner Callebaut, and Gerd M{\"u}ller made every aspect of the meeting run smoothly and effectively. But above all, we thank the participants who invested so much time, thought, and effort in their contributions to this meeting. This was the case not only for the individual presentations, but also—even more so—for the wonderfully enriching discussions that followed each talk and concluded the meeting. MAO thanks the Australian Research Council and University of Sydney for Future Fellowship Funding; OSS acknowledges funding from EPSRC Research Grant EP/1017445/1; MLS acknowledges funding from National Institutes of Health grants R01GM086673 and R01GM097415, and National Science Foundation grant IOS-1258078. Publisher Copyright: {\textcopyright} 2015, Konrad Lorenz Institute for Evolution and Cognition Research.",
year = "2015",
month = mar,
doi = "10.1007/s13752-015-0202-6",
language = "English (US)",
volume = "10",
pages = "6--17",
journal = "Biological Theory",
issn = "1555-5542",
publisher = "Springer Science and Business Media B.V.",
number = "1",
}