A photochromic agonist of AMPA receptors

Philipp Stawski, Martin Sumser, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue-green light. It can be used to effectively control neuronal activity in the mammalian brain.

Original languageEnglish (US)
Pages (from-to)5748-5751
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number23
StatePublished - Jun 4 2012


  • bioorganic chemistry
  • diazo compounds
  • optochemical genetics
  • photopharmacology
  • receptors

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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