A photochromic agonist of AMPA receptors

Philipp Stawski; Martin Sumser; Dirk Trauner

doi:10.1002/anie.201109265

A photochromic agonist of AMPA receptors

Philipp Stawski, Martin Sumser, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue-green light. It can be used to effectively control neuronal activity in the mammalian brain.

Original language	English (US)
Pages (from-to)	5748-5751
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	23
DOIs	https://doi.org/10.1002/anie.201109265
State	Published - Jun 4 2012

Keywords

bioorganic chemistry
diazo compounds
optochemical genetics
photopharmacology
receptors

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201109265

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A photochromic agonist of AMPA receptors

Abstract

Keywords

ASJC Scopus subject areas

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