A preliminary survey of the peptoid folding landscape

Glenn L. Butterfoss, P. Douglas Renfrew, Brian Kuhlman, Kent Kirshenbaum, Richard Bonneau

Research output: Contribution to journalArticle

Abstract

We present an analysis of the conformational preferences of N-substituted glycine peptoid oligomers. We survey the backbone conformations observed in experimentally determined peptoid structures and provide a comparison with high-level quantum mechanics calculations of short peptoid oligomers. The dominant sources of structural variation derive from: side-chain dependent cis/trans isomerization of backbone amide bonds, side chain stereochemistry, and flexibility in the psi dihedral angle. We find good agreement between the clustering of experimentally determined peptoid torsion angles and local torsional minima predicted by theory for a disarcosine model. The calculations describe a well-defined conformational map featuring distinct energy minima. The general features of the peptoid backbone conformational landscape are consistent across a range of N-alkyl glycine side chains. Alteration of side chain types, however, creates subtle but potentially significant variations in local folding propensities. We identify a limited number of low energy local conformations, which may be preferentially favored by incorporation of particular monomer units. Greater variation in backbone dihedral angles are accessible in peptoids featuring trans amide bond geometries. These results confirm that computational approaches can play a valuable role in guiding the design of complex peptoid architectures and may lead to strategies for introducing constraints that select among a limited number of low energy local conformations.

Original languageEnglish (US)
Pages (from-to)16798-16807
Number of pages10
JournalJournal of the American Chemical Society
Volume131
Issue number46
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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