A proton-shuttle reaction mechanism for histone deacetylase 8 and the catalytic role of metal ions

Chemistry

• Metal Ion 100%
• Histone 100%
• Base 40%
• Carboxamide 40%
• K+ 40%
• Potassium Ion 40%
• Nitrogen Atom 20%
• Acetyl 20%
• Molecular Dynamics 20%
• Gibbs Free Energy 20%
• Transition State 20%
• Antineoplastic Agent 20%
• Zinc Ion 20%
• Catalysis 20%
• Rate-Determining Step 20%
• Deacetylation 20%
• Alkalinity 20%
• Transition State Structure 20%

Keyphrases

• Shuttle Reactions 100%
• K+ Ion 66%
• Zinc-dependent 66%
• Class I HDACs 33%
• Transition State Stabilization 33%
• Ion Change 33%
• Class II HDAC 33%
• Bound Water Molecules 33%
• New Antitumor Drugs 33%
• Deacetylation Process 33%

Biochemistry, Genetics and Molecular Biology

• Histone Deacetylase 100%
• Gene Expression 25%
• Dynamics 25%
• Enzyme 25%
• Chromatin Structure 25%
• Histone 25%
• Umbrella Sampling 25%
• Catalytic Mechanism 25%
• Zinc Ion 25%
• Enzyme Mechanism 25%
• Nucleophilicity 25%
• Deacetylation 25%