A random walk down the genomes: DNA evolution in valis

Salvatore Paxia; Archisman Rudra; Yi Zhou; Bud Mishra

doi:10.1109/MC.2002.1016904

A random walk down the genomes: DNA evolution in valis

Salvatore Paxia, Archisman Rudra, Yi Zhou, Bud Mishra

Computer Science

Research output: Contribution to journal › Article › peer-review

Abstract

A better understanding of biology will come through information-theoretic studies of genomes that provide insights into DNA's role in governing metabolic and regulatory pathways. Understanding the evolutionary processes that act on these "codes of life" requires the ability to analyze vast amounts of continually generated genomic data. Researchers in the emerging bioinformatics discipline require more complex mechanisms to investigate the full ensemble of available biological facts. To meet this challenge, New York University's Bioinformatics Group is creating a computational environment called Valis - the vast active living intelligent system. Valis is designed to solve the immediate genomic and proteomic problems that the biological community currently faces, while remaining flexible enough to adapt to the maturing bioinformatics field.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	Computer
Volume	35
Issue number	7
DOIs	https://doi.org/10.1109/MC.2002.1016904
State	Published - Jul 2002

ASJC Scopus subject areas

General Computer Science

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10.1109/MC.2002.1016904

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title = "A random walk down the genomes: DNA evolution in valis",

abstract = "A better understanding of biology will come through information-theoretic studies of genomes that provide insights into DNA's role in governing metabolic and regulatory pathways. Understanding the evolutionary processes that act on these {"}codes of life{"} requires the ability to analyze vast amounts of continually generated genomic data. Researchers in the emerging bioinformatics discipline require more complex mechanisms to investigate the full ensemble of available biological facts. To meet this challenge, New York University's Bioinformatics Group is creating a computational environment called Valis - the vast active living intelligent system. Valis is designed to solve the immediate genomic and proteomic problems that the biological community currently faces, while remaining flexible enough to adapt to the maturing bioinformatics field.",

author = "Salvatore Paxia and Archisman Rudra and Yi Zhou and Bud Mishra",

note = "Funding Information: We thank Mike Wigler, Elizabeth Thomas, Misha Gromov, and Ale Carbone for offering many exciting ideas, useful contributions, and ways to think about genomes. Thomas Anantharaman, Dave Schwartz, Izzy Edelman, Jack Schwartz, Eric Siggia, Chris Wiggins, Gloria Coruzzi, Dan Tranchina, Suse Broyde, Phil Benfey, Harel Weinstein, Mike Seul, Bob Desnick, and many others indirectly contributed to our efforts. Valis is supported by grants from the National Institutes of Health; the NYU University Research Challenge Fund; the US Department of Energy; the New York State Office of Science, Technology, and Academic Research; DARPA; and an HHMI Biomedical Support Research Grant.",

year = "2002",

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doi = "10.1109/MC.2002.1016904",

language = "English (US)",

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AU - Paxia, Salvatore

AU - Rudra, Archisman

AU - Zhou, Yi

AU - Mishra, Bud

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A random walk down the genomes: DNA evolution in valis

Abstract

ASJC Scopus subject areas

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