A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh

Wendy J. Verret, Yu Chen, Alauddin Ahmed, Tariqul Islam, Faruque Parvez, Muhammad G. Kibriya, Joseph H. Graziano, Habibul Ahsan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We sought to determine whether supplementation of vitamin E (α-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions. Methods: A 2 × 2 randomized, placebo-controlled, double-blind trial among 121 men and women chronically exposed to arsenic in drinking water was conducted in rural Bangladesh. Participants were randomized to one of four treatment arms: vitamin E, selenium, vitamin E and selenium (combination), or placebo and were treated for 6 months. Results: At baseline, the average skin lesion scores were 2.23, 2.26, and 2.63 and at follow-up, the average skin lesion scores went down to 2.00, 2.06, and 2.47 in those receiving vitamin E, selenium, and the combination, respectively. Conclusions: Supplementation with vitamin E and selenium, either alone or in combination, slightly improved skin lesion status, although the improvement was not statistically significant.

Original languageEnglish (US)
Pages (from-to)1026-1035
Number of pages10
JournalJournal of Occupational and Environmental Medicine
Volume47
Issue number10
DOIs
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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