A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

Kara Gross Margolis

doi:10.1016/j.jchemneu.2017.02.001

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

Kara Gross Margolis

Molecular Pathobiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. The potential therapeutic value of 5-HT₄ modulation in the subsequent treatment of these conditions is also addressed.

Original language	English (US)
Pages (from-to)	36-40
Number of pages	5
Journal	Journal of chemical neuroanatomy
Volume	83-84
DOIs	https://doi.org/10.1016/j.jchemneu.2017.02.001
State	Published - Oct 2017

Keywords

5-HT receptor
Antidepressants
Autism spectrum disorders
Brain-gut axis
Selective serotonin reuptake inhibitors
Serotonin
Serotonin reuptake transporter

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1016/j.jchemneu.2017.02.001

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title = "A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure",

abstract = "Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. The potential therapeutic value of 5-HT4 modulation in the subsequent treatment of these conditions is also addressed.",

keywords = "5-HT receptor, Antidepressants, Autism spectrum disorders, Brain-gut axis, Selective serotonin reuptake inhibitors, Serotonin, Serotonin reuptake transporter",

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AB - Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. The potential therapeutic value of 5-HT4 modulation in the subsequent treatment of these conditions is also addressed.

KW - 5-HT receptor

KW - Antidepressants

KW - Autism spectrum disorders

KW - Brain-gut axis

KW - Selective serotonin reuptake inhibitors

KW - Serotonin

KW - Serotonin reuptake transporter

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AN - SCOPUS:85013403159

SN - 0891-0618

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JO - Journal of chemical neuroanatomy

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ER -

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

Abstract

Keywords

ASJC Scopus subject areas

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