A signal-passing DNA-strand-exchange mechanism for active self-assembly of DNA nanostructures

Jennifer E. Padilla, Ruojie Sha, Martin Kristiansen, Junghuei Chen, Natasha Jonoska, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


DNA nanostructured tiles play an active role in their own self-assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self-assembly of tiles and enables local communication during the self-assembly process. This localized signal-passing mechanism provides a new element of control for autonomous self-assembly of DNA nanostructures.

Original languageEnglish (US)
Pages (from-to)5939-5942
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number20
StatePublished - May 11 2015


  • DNA structures
  • DNA tiles
  • nanotechnology
  • self-assembly
  • strand displacement

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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