A simple DNA-based translation system

Alejandra V. Garibotti, Shiping Liao, Nadrian C. Seeman

Research output: Contribution to journalArticle


We have used DNA double crossover (DX) molecules to produce a translation system that generates unique molecular products. The particular species of DX molecule used contains an even number of half-turns between crossover points, so there is a continuous strand on both sides of the molecule. One of these strands acts as the input strand containing the message, and a second strand acts as the product of translation. The crossover strands carry the "code" that connects the two sides of the molecule. This system is more robust, more extendable, and simpler than previous DNA-based translation systems that have been reported. It is designed to be useful in a variety of applications that utilize the concept of translating from one code to another.

Original languageEnglish (US)
Pages (from-to)480-483
Number of pages4
JournalNano Letters
Issue number2
StatePublished - Feb 1 2007


ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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