A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids

Leo A. Joyce; Marc S. Maynor; Justin M. Dragna; Gabriella M. Da Cruz; Vincent M. Lynch; James W. Canary; Eric V. Anslyn

doi:10.1021/ja205775g

A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids

Leo A. Joyce, Marc S. Maynor, Justin M. Dragna, Gabriella M. Da Cruz, Vincent M. Lynch, James W. Canary, Eric V. Anslyn

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The association between an achiral copper(II) host (1) and chiral carboxylate guests was studied using exciton-coupled circular dichroism (ECCD). Enantiomeric complexes were created upon binding of the enantiomers of the carboxylate guests to the host, and the sign of the resultant CD signal allowed for determination of the configuration of the studied guest. The difference in magnitudes and shapes of the CD signals, in conjunction with linear discriminant analysis (LDA), allowed for the identity of the guest to be determined successfully. A model was created for the host-guest complexes which successfully predicts the sign of the observed CD signal. Further, Taft parameters were used in the model, leading to rationalization of the observed magnitudes of the CD signals. Finally, the enantiomeric excess (ee) of unknown samples of three chiral carboxylic acid guests was determined with an average absolute error of ±3.0%.

Original language	English (US)
Pages (from-to)	13746-13752
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	133
Issue number	34
DOIs	https://doi.org/10.1021/ja205775g
State	Published - Aug 31 2011

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja205775g

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title = "A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids",

abstract = "The association between an achiral copper(II) host (1) and chiral carboxylate guests was studied using exciton-coupled circular dichroism (ECCD). Enantiomeric complexes were created upon binding of the enantiomers of the carboxylate guests to the host, and the sign of the resultant CD signal allowed for determination of the configuration of the studied guest. The difference in magnitudes and shapes of the CD signals, in conjunction with linear discriminant analysis (LDA), allowed for the identity of the guest to be determined successfully. A model was created for the host-guest complexes which successfully predicts the sign of the observed CD signal. Further, Taft parameters were used in the model, leading to rationalization of the observed magnitudes of the CD signals. Finally, the enantiomeric excess (ee) of unknown samples of three chiral carboxylic acid guests was determined with an average absolute error of ±3.0%.",

author = "Joyce, {Leo A.} and Maynor, {Marc S.} and Dragna, {Justin M.} and {Da Cruz}, {Gabriella M.} and Lynch, {Vincent M.} and Canary, {James W.} and Anslyn, {Eric V.}",

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T1 - A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids

AU - Joyce, Leo A.

AU - Maynor, Marc S.

AU - Dragna, Justin M.

AU - Da Cruz, Gabriella M.

AU - Lynch, Vincent M.

AU - Canary, James W.

AU - Anslyn, Eric V.

PY - 2011/8/31

Y1 - 2011/8/31

N2 - The association between an achiral copper(II) host (1) and chiral carboxylate guests was studied using exciton-coupled circular dichroism (ECCD). Enantiomeric complexes were created upon binding of the enantiomers of the carboxylate guests to the host, and the sign of the resultant CD signal allowed for determination of the configuration of the studied guest. The difference in magnitudes and shapes of the CD signals, in conjunction with linear discriminant analysis (LDA), allowed for the identity of the guest to be determined successfully. A model was created for the host-guest complexes which successfully predicts the sign of the observed CD signal. Further, Taft parameters were used in the model, leading to rationalization of the observed magnitudes of the CD signals. Finally, the enantiomeric excess (ee) of unknown samples of three chiral carboxylic acid guests was determined with an average absolute error of ±3.0%.

AB - The association between an achiral copper(II) host (1) and chiral carboxylate guests was studied using exciton-coupled circular dichroism (ECCD). Enantiomeric complexes were created upon binding of the enantiomers of the carboxylate guests to the host, and the sign of the resultant CD signal allowed for determination of the configuration of the studied guest. The difference in magnitudes and shapes of the CD signals, in conjunction with linear discriminant analysis (LDA), allowed for the identity of the guest to be determined successfully. A model was created for the host-guest complexes which successfully predicts the sign of the observed CD signal. Further, Taft parameters were used in the model, leading to rationalization of the observed magnitudes of the CD signals. Finally, the enantiomeric excess (ee) of unknown samples of three chiral carboxylic acid guests was determined with an average absolute error of ±3.0%.

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A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids

Abstract

ASJC Scopus subject areas

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