A stereodynamic tripodal ligand with three different coordinating arms: Synthesis and zinc(II), copper(I) complexation study

Jian Liang, James W. Canary

Research output: Contribution to journalArticlepeer-review

Abstract

A tetradentate tripodal ligand containing a chiral center and three different coordinating arms was designed and synthesized. Its complexation properties with ZnII and CuI were studied by NMR and optical spectroscopy. NMR experiments demonstrated the formation of two diastereomers, indicating the stabilization of the central tertiary amine configuration by metal coordination. The inversion of pyramidalization of the central tertiary amine of the ligand was found to be highly dependent upon metal ion, solvent, and temperature. Dynamic NMR measurements were used to estimate the energy of activation required for nitrogen atom inversion. Finally, absorption and circular dichroism measurements confirmed the expectation that metal complexes of the ligand gave rise to circular dichroism but that such spectra were not characterized by exciton-coupling, in contrast to previously described ligands containing two identical arms with strong chromophores.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalChirality
Volume23
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Variable temperature NMR
  • coalescence
  • dynamic exchange
  • nitrogen inversion
  • tripodal ligand

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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