A stochastic model to evaluate options for antenatal genetic screening

Steve Gallivan; Mark Jit; Martin Utley

doi:10.1007/s10729-006-7660-0

A stochastic model to evaluate options for antenatal genetic screening

Steve Gallivan, Mark Jit, Martin Utley

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Haemoglobinopathies are a group of genetic disorders which are particularly prevalent among certain risk groups such as ethnic groups. Antenatal screening of potential haemoglobinopathy carriers allows early diagnosis for affected fetuses, leading to therapeutic intervention or termination. However, it has drawbacks such as screening costs and possible miscarriage as a result of fetal testing. This paper describes a model that allows the outcomes of a screening programme to be estimated for different risk groups. The model has been implemented as a computer package that can be used to inform decisions made by health care planners.

Original language	English (US)
Pages (from-to)	111-124
Number of pages	14
Journal	Health Care Management Science
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/s10729-006-7660-0
State	Published - May 2006

Keywords

Antenatal screening
Computer models
Genetic screening
Haemoglobinopathies
Mathematical modelling
Stochastic models

ASJC Scopus subject areas

Medicine (miscellaneous)
General Health Professions

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10.1007/s10729-006-7660-0

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KW - Stochastic models

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A stochastic model to evaluate options for antenatal genetic screening

Abstract

Keywords

ASJC Scopus subject areas

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