TY - JOUR
T1 - A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers
AU - Qiu, Yuqing
AU - Nguyen, Michael
AU - Hocky, Glen M.
AU - Dinner, Aaron R.
AU - Vaikuntanathan, Suriyanarayanan
N1 - Funding Information:
This work was mainly supported by a Department of Energy Basic Energy Sciences Grant DE-SC0019765 (to S.V., Y.Q., and M.N.). Y.Q. was also supported by a Yen Fellowship and the University of Chicago Materials Research Science and Engineering Center, which is funded by the National Science Foundation under Award DMR-2011854. M.N. was also supported by an NSF graduate research fellowship. G.M.H. was supported by National Institutes of Health Award R35 GM138312. A.R.D. was supported by NIH award R35 GM136381. We thank Chatipat Lorpaiboon for helpful discussion. Simulations were performed on the Midway cluster of the University of Chicago Research Computing Center.
Funding Information:
ACKNOWLEDGMENTS. This work was mainly supported by a Department of Energy Basic Energy Sciences Grant DE-SC0019765 (to S.V., Y.Q., and M.N.). Y.Q. was also supported by a Yen Fellowship and the University of Chicago Materials Research Science and Engineering Center, which is funded by the National Science Foundation under Award DMR-2011854. M.N. was also supported by an NSF graduate research fellowship. G.M.H. was supported by National Institutes of Health Award R35 GM138312. A.R.D. was supported by NIH award R35 GM136381. We thank Chatipat Lorpaiboon for helpful discussion. Simulations were performed on the Midway cluster of the University of Chicago Research Computing Center.
Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.
PY - 2021/9/21
Y1 - 2021/9/21
N2 - Understanding the role of nonequilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and nonequilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle cross-linked by two competing types of actin-binding proteins [S. L. Freedman et al., Proc. Natl. Acad. Sci. U.S.A. 116, 16192-16197 (2019)], we construct a minimal model for such a system and show that the dynamics of a growing actin bundle are subject to a set of thermodynamic constraints that relate its nonequilibrium driving, morphology, and molecular fluxes. The thermodynamic constraints reveal the importance of correlations between these molecular fluxes and offer a route to estimating microscopic driving forces from microscopy experiments.
AB - Understanding the role of nonequilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and nonequilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle cross-linked by two competing types of actin-binding proteins [S. L. Freedman et al., Proc. Natl. Acad. Sci. U.S.A. 116, 16192-16197 (2019)], we construct a minimal model for such a system and show that the dynamics of a growing actin bundle are subject to a set of thermodynamic constraints that relate its nonequilibrium driving, morphology, and molecular fluxes. The thermodynamic constraints reveal the importance of correlations between these molecular fluxes and offer a route to estimating microscopic driving forces from microscopy experiments.
KW - Actin bundling
KW - Fluctuation-response relations
KW - Growth
KW - Microscopic nonequilibrium driving
KW - Stochastic thermodynamics
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U2 - 10.1073/pnas.2102881118
DO - 10.1073/pnas.2102881118
M3 - Article
C2 - 34518221
AN - SCOPUS:85114853915
SN - 0027-8424
VL - 118
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 38
M1 - e2102881118
ER -