A supramolecular approach for preparation of size-controlled nanoparticles

Hao Wang, Shutao Wang, Helen Su, Kuan Ju Chen, Amanda Lee Armijo, Wei Yu Lin, Yanju Wang, Jing Sun, Ken Ichiro Kamei, Johannes Czernin, Caius G. Radu, Hsian Rong Tseng

Research output: Contribution to journalArticlepeer-review


A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30-450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture).

Original languageEnglish (US)
Pages (from-to)4344-4348
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number24
StatePublished - Jun 2 2009


  • Adamantanes
  • Biodistribution
  • Cyclodextrins
  • Nanoparticles
  • Positron emission tomography

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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