A Tetraguanidinium Ligand Binds to the Surface of the Tetramerization Domain of Protein P53

Xavier Salvatella; Marc Martinell; Margarida Gairí; Mauricio G. Mateu; Miguel Feliz; Andrew D. Hamilton; Javier De Mendoza; Ernest Giralt

doi:10.1002/anie.200352115

A Tetraguanidinium Ligand Binds to the Surface of the Tetramerization Domain of Protein P53

Xavier Salvatella, Marc Martinell, Margarida Gairí, Mauricio G. Mateu, Miguel Feliz, Andrew D. Hamilton, Javier De Mendoza, Ernest Giralt

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A key therapeutic target in the fight against cancer, the tetramerization domain of the tumor suppressor protein P53 binds a tetraguanidinium ligand at its surface. A specific interaction involving four salt bridges was detected by two NMR-based techniques (see figure). The design of protein-surface ligands is a major challenge because of competition between the ligand and water molecules.

Original language	English (US)
Pages (from-to)	196-198
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/anie.200352115
State	Published - Dec 29 2003

Keywords

Host-guest systems
Ligand design
Molecular recognition
NMR spectroscopy
Proteins

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200352115

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abstract = "A key therapeutic target in the fight against cancer, the tetramerization domain of the tumor suppressor protein P53 binds a tetraguanidinium ligand at its surface. A specific interaction involving four salt bridges was detected by two NMR-based techniques (see figure). The design of protein-surface ligands is a major challenge because of competition between the ligand and water molecules.",

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AU - Salvatella, Xavier

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AU - Gairí, Margarida

AU - Mateu, Mauricio G.

AU - Feliz, Miguel

AU - Hamilton, Andrew D.

AU - De Mendoza, Javier

AU - Giralt, Ernest

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KW - Host-guest systems

KW - Ligand design

KW - Molecular recognition

KW - NMR spectroscopy

KW - Proteins

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A Tetraguanidinium Ligand Binds to the Surface of the Tetramerization Domain of Protein P53

Abstract

Keywords

ASJC Scopus subject areas

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