A Thermodynamic Model of the Lamellar to Inverse Hexagonal Phase Transition of Lipid Membrane-Water Systems

Gregory L. Kirk; Sol M. Gruner; D. L. Stein

doi:10.1021/bi00301a009

A Thermodynamic Model of the Lamellar to Inverse Hexagonal Phase Transition of Lipid Membrane-Water Systems

Gregory L. Kirk, Sol M. Gruner, D. L. Stein

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Abstract

A theoretical model of the lamellar (L_α) to inverted hexagonal (H_II) phase transition is developed for mixtures of water and biological lipids. A free energy per lipid molecule is calculated for each phase as the sum of four lattice-specific terms: a local elastic term and global terms involving the packing of hydrocarbon chains, Debye-shielded electrostatics, and hydration effects. A critical lipid concentration for the transition is indicated by the concentration where the net lamellar and hexagonal free energies are equal. The relevance of the model to membrane interactions in biological systems is discussed. Suggestions are made for introducing temperature dependence into the model, and experiments are proposed to investigate the principal opposing forces in the model.

Original language	English (US)
Pages (from-to)	1093-1102
Number of pages	10
Journal	Biochemistry
Volume	23
Issue number	6
DOIs	https://doi.org/10.1021/bi00301a009
State	Published - Mar 1984

ASJC Scopus subject areas

Biochemistry

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10.1021/bi00301a009

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abstract = "A theoretical model of the lamellar (Lα) to inverted hexagonal (HII) phase transition is developed for mixtures of water and biological lipids. A free energy per lipid molecule is calculated for each phase as the sum of four lattice-specific terms: a local elastic term and global terms involving the packing of hydrocarbon chains, Debye-shielded electrostatics, and hydration effects. A critical lipid concentration for the transition is indicated by the concentration where the net lamellar and hexagonal free energies are equal. The relevance of the model to membrane interactions in biological systems is discussed. Suggestions are made for introducing temperature dependence into the model, and experiments are proposed to investigate the principal opposing forces in the model.",

author = "Kirk, {Gregory L.} and Gruner, {Sol M.} and Stein, {D. L.}",

year = "1984",

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Y1 - 1984/3

N2 - A theoretical model of the lamellar (Lα) to inverted hexagonal (HII) phase transition is developed for mixtures of water and biological lipids. A free energy per lipid molecule is calculated for each phase as the sum of four lattice-specific terms: a local elastic term and global terms involving the packing of hydrocarbon chains, Debye-shielded electrostatics, and hydration effects. A critical lipid concentration for the transition is indicated by the concentration where the net lamellar and hexagonal free energies are equal. The relevance of the model to membrane interactions in biological systems is discussed. Suggestions are made for introducing temperature dependence into the model, and experiments are proposed to investigate the principal opposing forces in the model.

AB - A theoretical model of the lamellar (Lα) to inverted hexagonal (HII) phase transition is developed for mixtures of water and biological lipids. A free energy per lipid molecule is calculated for each phase as the sum of four lattice-specific terms: a local elastic term and global terms involving the packing of hydrocarbon chains, Debye-shielded electrostatics, and hydration effects. A critical lipid concentration for the transition is indicated by the concentration where the net lamellar and hexagonal free energies are equal. The relevance of the model to membrane interactions in biological systems is discussed. Suggestions are made for introducing temperature dependence into the model, and experiments are proposed to investigate the principal opposing forces in the model.

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A Thermodynamic Model of the Lamellar to Inverse Hexagonal Phase Transition of Lipid Membrane-Water Systems

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