A transcription factor hierarchy defines an environmental stress response network

Liang Song, Shao Shan Carol Huang, Aaron Wise, Rosa Castanoz, Joseph R. Nery, Huaming Chen, Marina Watanabe, Jerushah Thomas, Ziv Bar-Joseph, Joseph R. Ecker

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Environmental stresses are universally encountered by microbes, plants, and animals.Yet systematic studies of stress-responsive transcription factor (TF) networks in multicellular organisms have been limited.The phytohormone abscisic acid (ABA) influences the expression of thousands of genes, allowing us to characterize complex stress-responsive regulatory networks. Using chromatin immunoprecipitation sequencing, we identified genome-wide targets of 21 ABA-related TFs to construct a comprehensive regulatory network in Arabidopsis thaliana. Determinants of dynamic TF binding and a hierarchy among TFs were defined, illuminating the relationship between differential gene expression patterns and ABA pathway feedback regulation. By extrapolating regulatory characteristics of observed canonical ABA pathway components, we identified a new family of transcriptional regulators modulating ABA and salt responsiveness and demonstrated their utility to modulate plant resilience to osmotic stress.

Original languageEnglish (US)
Article numberaag1550
Issue number6312
StatePublished - Nov 4 2016

ASJC Scopus subject areas

  • General

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    Song, L., Huang, S. S. C., Wise, A., Castanoz, R., Nery, J. R., Chen, H., Watanabe, M., Thomas, J., Bar-Joseph, Z., & Ecker, J. R. (2016). A transcription factor hierarchy defines an environmental stress response network. Science, 354(6312), [aag1550]. https://doi.org/10.1126/science.aag1550