TY - JOUR
T1 - A Unique Class of Neural Progenitors in the Drosophila Optic Lobe Generates Both Migrating Neurons and Glia
AU - Chen, Zhenqing
AU - Del Valle Rodriguez, Alberto
AU - Li, Xin
AU - Erclik, Ted
AU - Fernandes, Vilaiwan M.
AU - Desplan, Claude
N1 - Funding Information:
We thank the fly community, The DSHB, and the BDSC for antibodies and fly stocks. We thank R. Mann for suggestions and reagents and Claire Bertet, Filipe Pinto Teixeira Sousa, Nathalie Neriec, Jens Rister, and other Desplan laboratory members for intellectual input and support. This work was supported by National Institutes of Health grant R01 EY13012 (to C.D.), The Robert Leet and Clara Guthrie Patterson Trust Postdoctoral Fellowship (to X.L.), The Canadian Institutes of Health Research (to T.E.), and a Natural Sciences and Engineering Research Council of Canada fellowship (to V.M.F.).
Publisher Copyright:
© 2016 The Authors.
PY - 2016/4/26
Y1 - 2016/4/26
N2 - How neuronal and glial fates are specified from neural precursor cells is an important question for developmental neurobiologists. We address this question in the Drosophila optic lobe, composed of the lamina, medulla, and lobula complex. We show that two gliogenic regions posterior to the prospective lamina also produce lamina wide-field (Lawf) neurons, which share common progenitors with lamina glia. These progenitors express neither canonical neuroblast nor lamina precursor cell markers. They bifurcate into two sub-lineages in response to Notch signaling, generating lamina glia or Lawf neurons, respectively. The newly born glia and Lawfs then migrate tangentially over substantial distances to reach their target tissue. Thus, Lawf neurogenesis, which includes a common origin with glia, as well as neuronal migration, resembles several aspects of vertebrate neurogenesis. Chen et al. report an unusual class of progenitor cells, which bifurcate into lineages of migrating lamina glia and migrating Lawf neurons. The common progenitors differ from typical Drosophila neuroblasts. The Notch pathway mediates the fate choice between the glial and neuronal precursors, resembling the glia/neuron fate choice in vertebrates.
AB - How neuronal and glial fates are specified from neural precursor cells is an important question for developmental neurobiologists. We address this question in the Drosophila optic lobe, composed of the lamina, medulla, and lobula complex. We show that two gliogenic regions posterior to the prospective lamina also produce lamina wide-field (Lawf) neurons, which share common progenitors with lamina glia. These progenitors express neither canonical neuroblast nor lamina precursor cell markers. They bifurcate into two sub-lineages in response to Notch signaling, generating lamina glia or Lawf neurons, respectively. The newly born glia and Lawfs then migrate tangentially over substantial distances to reach their target tissue. Thus, Lawf neurogenesis, which includes a common origin with glia, as well as neuronal migration, resembles several aspects of vertebrate neurogenesis. Chen et al. report an unusual class of progenitor cells, which bifurcate into lineages of migrating lamina glia and migrating Lawf neurons. The common progenitors differ from typical Drosophila neuroblasts. The Notch pathway mediates the fate choice between the glial and neuronal precursors, resembling the glia/neuron fate choice in vertebrates.
UR - http://www.scopus.com/inward/record.url?scp=84963543120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963543120&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2016.03.061
DO - 10.1016/j.celrep.2016.03.061
M3 - Article
AN - SCOPUS:84963543120
SN - 2211-1247
VL - 15
SP - 774
EP - 786
JO - Cell Reports
JF - Cell Reports
IS - 4
ER -