A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

M. L. Flexman, H. K. Kim, R. Stoll, M. A. Khalil, C. J. Fong, A. H. Hielscher

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid ®, ink, and dye.

    Original languageEnglish (US)
    Article number033108
    JournalReview of Scientific Instruments
    Volume83
    Issue number3
    DOIs
    StatePublished - Mar 2012

    ASJC Scopus subject areas

    • Instrumentation

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