A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

M. L. Flexman; H. K. Kim; R. Stoll; M. A. Khalil; C. J. Fong; A. H. Hielscher

doi:10.1063/1.3694494

A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

M. L. Flexman, H. K. Kim, R. Stoll, M. A. Khalil, C. J. Fong, A. H. Hielscher

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid ^®, ink, and dye.

Original language	English (US)
Article number	033108
Journal	Review of Scientific Instruments
Volume	83
Issue number	3
DOIs	https://doi.org/10.1063/1.3694494
State	Published - Mar 2012

ASJC Scopus subject areas

Instrumentation

Access to Document

10.1063/1.3694494

Cite this

@article{b64474f8c4db4cb1850336d0832a556b,

title = "A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue",

abstract = "We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid {\textregistered}, ink, and dye.",

author = "Flexman, {M. L.} and Kim, {H. K.} and R. Stoll and Khalil, {M. A.} and Fong, {C. J.} and Hielscher, {A. H.}",

note = "Funding Information: This work was supported in part by the National Cancer Institute at the National Institutes of Health (Grant Nos. NCI-5R33CA118666 and NCI-U54CA126513-039001). Molly Flexman is partially supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).",

year = "2012",

month = mar,

doi = "10.1063/1.3694494",

language = "English (US)",

volume = "83",

journal = "Review of Scientific Instruments",

issn = "0034-6748",

publisher = "American Institute of Physics Publising LLC",

number = "3",

}

TY - JOUR

T1 - A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

AU - Flexman, M. L.

AU - Kim, H. K.

AU - Stoll, R.

AU - Khalil, M. A.

AU - Fong, C. J.

AU - Hielscher, A. H.

N1 - Funding Information: This work was supported in part by the National Cancer Institute at the National Institutes of Health (Grant Nos. NCI-5R33CA118666 and NCI-U54CA126513-039001). Molly Flexman is partially supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

PY - 2012/3

Y1 - 2012/3

N2 - We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid ®, ink, and dye.

AB - We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid ®, ink, and dye.

UR - http://www.scopus.com/inward/record.url?scp=84861614298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861614298&partnerID=8YFLogxK

U2 - 10.1063/1.3694494

DO - 10.1063/1.3694494

M3 - Article

C2 - 22462907

AN - SCOPUS:84861614298

SN - 0034-6748

VL - 83

JO - Review of Scientific Instruments

JF - Review of Scientific Instruments

IS - 3

M1 - 033108

ER -

A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this