Ab initio protein structure prediction: Progress and prospects

R. Bonneau, D. Baker

Research output: Contribution to journalReview articlepeer-review


Considerable recent progress has been made in the field of ab initio protein structure prediction, as witnessed by the third Critical Assessment of Structure Prediction (CASP3). In spite of this progress, much work remains, for the field has yet to produce consistently reliable ab initio structure prediction protocols. In this work, we review the features of current ab initio protocols in an attempt to highlight the foundations of recent progress in the field and suggest promising directions for future work.

Original languageEnglish (US)
Pages (from-to)173-189
Number of pages17
JournalAnnual Review of Biophysics and Biomolecular Structure
StatePublished - 2001


  • Structural genomics, protein folding, scoring functions, fold prediction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology


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