The concept of molecular workbenches is introduced. These workbenches are rigid templates onto which the substrate is fixed covalently and is thus arranged in a conformationally defined way. The workbench may be disconnectible (i.e. after the functionalization of the substrate it is removed by bond cleavage) or non-disconnectible. In this case the workbench is irreversibly incorporated into the target structure. This concept is illustrated by additions to (E) olefins (disconnectible workbench) and a synthesis of dihydrocodeinone (non-disconnectible workbench).
ASJC Scopus subject areas
- Chemical Engineering(all)