Absolute configurations of N,N-dialkyl α-amino acids and β-amino alcohols from exciton-coupled circular dichroism spectra of Cu(II) complexes

Steffen Zahn; James W. Canary

doi:10.1021/ol990715a

Absolute configurations of N,N-dialkyl α-amino acids and β-amino alcohols from exciton-coupled circular dichroism spectra of Cu(II) complexes

Steffen Zahn, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(equation presented) A circular dichroism technique has been applied to the absolute configurational assignment of acyclic α-amino acids and β-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.

Original language	English (US)
Pages (from-to)	861-864
Number of pages	4
Journal	Organic Letters
Volume	1
Issue number	6
DOIs	https://doi.org/10.1021/ol990715a
State	Published - Sep 23 1999

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol990715a

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abstract = "(equation presented) A circular dichroism technique has been applied to the absolute configurational assignment of acyclic α-amino acids and β-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.",

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N2 - (equation presented) A circular dichroism technique has been applied to the absolute configurational assignment of acyclic α-amino acids and β-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.

AB - (equation presented) A circular dichroism technique has been applied to the absolute configurational assignment of acyclic α-amino acids and β-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.

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Absolute configurations of N,N-dialkyl α-amino acids and β-amino alcohols from exciton-coupled circular dichroism spectra of Cu(II) complexes

Abstract

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