Absolute configurations of N,N-dialkyl α-amino acids and β-amino alcohols from exciton-coupled circular dichroism spectra of Cu(II) complexes

Steffen Zahn, James W. Canary

Research output: Contribution to journalArticlepeer-review

Abstract

(equation presented) A circular dichroism technique has been applied to the absolute configurational assignment of acyclic α-amino acids and β-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.

Original languageEnglish (US)
Pages (from-to)861-864
Number of pages4
JournalOrganic Letters
Volume1
Issue number6
DOIs
StatePublished - Sep 23 1999

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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