### Abstract

Phase-contrast (PC) cine MRI is a promising method for assessment of pathologic hemodynamics, including cardiovascular and hepatoportal vascular dynamics, but its low data acquisition efficiency limits the achievable spatial and temporal resolutions within clinically acceptable breath-hold durations. We propose to accelerate PC cine MRI using an approach which combines compressed sensing and parallel imaging (k-t SPARSE-SENSE). We validated the proposed 6-fold accelerated PC cine MRI against 3-fold accelerated PC cine MRI with parallel imaging (generalized autocalibrating partially parallel acquisitions). With the programmable flow pump, we simulated a time varying waveform emulating hepatic blood flow. Normalized root mean square error between two sets of velocity measurements was 2.59%. In multiple blood vessels of 12 control subjects, two sets of mean velocity measurements were in good agreement (mean difference = -0.29 cm/s; lower and upper 95% limits of agreement = -5.26 and 4.67 cm/s, respectively). The mean phase noise, defined as the standard deviation of the phase in a homogeneous stationary region, was significantly lower for k-t SPARSE-SENSE than for generalized autocalibrating partially parallel acquisitions (0.05 ± 0.01 vs. 0.19 ± 0.06 radians, respectively; P < 0.01). The proposed 6-fold accelerated PC cine MRI pulse sequence with k-t SPARSE-SENSE is a promising investigational method for rapid velocity measurement with relatively high spatial (1.7 mm A- 1.7 mm) and temporal (∼35 ms) resolutions.

Original language | English (US) |
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Pages (from-to) | 1054-1064 |

Number of pages | 11 |

Journal | Magnetic resonance in medicine |

Volume | 67 |

Issue number | 4 |

DOIs | |

State | Published - Apr 2012 |

### Keywords

- MRI
- PC MRI
- blood flow
- compressed sensing
- liver
- parallel imaging
- velocity

### ASJC Scopus subject areas

- Radiology Nuclear Medicine and imaging

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## Cite this

*Magnetic resonance in medicine*,

*67*(4), 1054-1064. https://doi.org/10.1002/mrm.23088