Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements

Julie Akiko Heck, David Gresham, David Botstein, Eric Alani

Research output: Contribution to journalArticle

Abstract

We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for ∼160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected despite dramatic decreases in spore viability, suggesting that frameshift and/or other unrepaired DNA replication lesions play a greater role than chromosomal instability in decreasing viability in MMR-defective strains.

Original languageEnglish (US)
Pages (from-to)519-523
Number of pages5
JournalGenetics
Volume174
Issue number1
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Genetics

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