TY - JOUR
T1 - Actigraphy-derived rest - Activity rhythms are associated with nocturnal blood pressure in young women
AU - Hoopes, Elissa K.
AU - Patterson, Freda
AU - Berube, Felicia R.
AU - D'agata, Michele N.
AU - Brewer, Benjamin
AU - Malone, Susan K.
AU - Farquhar, William B.
AU - Witman, Melissa A.
N1 - Funding Information:
Funding sources: This study was supported, in part, by the National Institute of General Medical Sciences P20GM113125, the National Institute on Minority Health and Health Disparities R01MD012734, and the National Institute on Drug Abuse R01DA051321.
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Introduction:Misalignment between lifestyle behaviors and endogenous circadian rhythms is associated with elevated nocturnal blood pressure (BP) in experimental studies; however, less is known about free-living (i.e. nonlaboratory) circadian disruption and nocturnal BP. Additionally, sex-specific cardiovascular implications of circadian disruption are unclear.Objective:To examine the associations between rest - activity rhythms (RAR), a field-based estimate of circadian disruption, and nocturnal BP characteristics in young men and women.Methods:Fifty participants (20 ± 1 years; 20 men/30 women) underwent 24-h ambulatory BP monitoring following 14 days of wrist actigraphy. RAR variables of interdaily stability (day-to-day consistency in RAR), intradaily variability (within-day fragmentation of RAR), and relative amplitude (difference between peak vs. trough activity) were derived from actigraphy. Multivariable regression models of mean nocturnal SBP, DBP, and SBP dipping were generated to test main associations with RAR variables, and sex × RAR interactions. Daytime BP, race, BMI, physical activity, sleep duration, alcohol, caffeine, and sodium intake were considered as covariates.Results:In the full sample, no main associations between RAR and nocturnal BP characteristics were found. Sex interacted with RAR such that in women, higher interdaily stability (β = -5.39, 95% CI = -10.04 to -0.73, P = 0.024) and relative amplitude (β = -4.78, 95% CI = -9.22 to -0.34, P = 0.036) were both associated with lower nocturnal SBP. Sex-stratified multivariable models of nocturnal BP also revealed associations between interdaily stability and relative amplitude with SBP dipping in women (all P ≤ 0.01). No associations were apparent in men.Conclusion:Consistent and high-amplitude RAR are favorably associated with nocturnal BP characteristics in young women.
AB - Introduction:Misalignment between lifestyle behaviors and endogenous circadian rhythms is associated with elevated nocturnal blood pressure (BP) in experimental studies; however, less is known about free-living (i.e. nonlaboratory) circadian disruption and nocturnal BP. Additionally, sex-specific cardiovascular implications of circadian disruption are unclear.Objective:To examine the associations between rest - activity rhythms (RAR), a field-based estimate of circadian disruption, and nocturnal BP characteristics in young men and women.Methods:Fifty participants (20 ± 1 years; 20 men/30 women) underwent 24-h ambulatory BP monitoring following 14 days of wrist actigraphy. RAR variables of interdaily stability (day-to-day consistency in RAR), intradaily variability (within-day fragmentation of RAR), and relative amplitude (difference between peak vs. trough activity) were derived from actigraphy. Multivariable regression models of mean nocturnal SBP, DBP, and SBP dipping were generated to test main associations with RAR variables, and sex × RAR interactions. Daytime BP, race, BMI, physical activity, sleep duration, alcohol, caffeine, and sodium intake were considered as covariates.Results:In the full sample, no main associations between RAR and nocturnal BP characteristics were found. Sex interacted with RAR such that in women, higher interdaily stability (β = -5.39, 95% CI = -10.04 to -0.73, P = 0.024) and relative amplitude (β = -4.78, 95% CI = -9.22 to -0.34, P = 0.036) were both associated with lower nocturnal SBP. Sex-stratified multivariable models of nocturnal BP also revealed associations between interdaily stability and relative amplitude with SBP dipping in women (all P ≤ 0.01). No associations were apparent in men.Conclusion:Consistent and high-amplitude RAR are favorably associated with nocturnal BP characteristics in young women.
KW - actigraphy
KW - ambulatory blood pressure
KW - interdaily stability
KW - intradaily variability
KW - relative amplitude
KW - sex-specific
KW - young adults
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U2 - 10.1097/HJH.0000000000002966
DO - 10.1097/HJH.0000000000002966
M3 - Article
C2 - 34387571
AN - SCOPUS:85121951795
SN - 0263-6352
VL - 39
SP - 2413
EP - 2421
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 12
ER -