Activation of promutagens by liver homogenates isolated from female mice at different ages; lack of significant differences

Joseph B. Guttenplan, Emile G. Bliznakov

Research output: Contribution to journalArticlepeer-review

Abstract

Liver S-9 (9000 g supernatant) fractions isolated from 2-, 12- and 26-month untreated female Swiss-Webster mice were compared under different assay conditions as to their abilities to activate 2-acetylaminofluorene, benzo(a)pyrene, and dimethylnitrosamine to mutagens in Salmonella typhimurium tester strain TA 100. All fractions activated these compounds to mutagens, although 2-acetylaminofluorene was only weakly mutagenic. Some differences in the activating abilities of the three age groups were observed but they were for the most part relatively small.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalMechanisms of Ageing and Development
Volume16
Issue number1
DOIs
StatePublished - May 1981

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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