TY - JOUR
T1 - Activation of promutagens by liver homogenates isolated from female mice at different ages; lack of significant differences
AU - Guttenplan, Joseph B.
AU - Bliznakov, Emile G.
N1 - Funding Information:
Supported in part by USPHS Grant CA-19023 (JBG) and research programs supported in part by grants from individuals, corporations and the following foundations:
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/5
Y1 - 1981/5
N2 - Liver S-9 (9000 g supernatant) fractions isolated from 2-, 12- and 26-month untreated female Swiss-Webster mice were compared under different assay conditions as to their abilities to activate 2-acetylaminofluorene, benzo(a)pyrene, and dimethylnitrosamine to mutagens in Salmonella typhimurium tester strain TA 100. All fractions activated these compounds to mutagens, although 2-acetylaminofluorene was only weakly mutagenic. Some differences in the activating abilities of the three age groups were observed but they were for the most part relatively small.
AB - Liver S-9 (9000 g supernatant) fractions isolated from 2-, 12- and 26-month untreated female Swiss-Webster mice were compared under different assay conditions as to their abilities to activate 2-acetylaminofluorene, benzo(a)pyrene, and dimethylnitrosamine to mutagens in Salmonella typhimurium tester strain TA 100. All fractions activated these compounds to mutagens, although 2-acetylaminofluorene was only weakly mutagenic. Some differences in the activating abilities of the three age groups were observed but they were for the most part relatively small.
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U2 - 10.1016/0047-6374(81)90029-4
DO - 10.1016/0047-6374(81)90029-4
M3 - Article
C2 - 6265715
AN - SCOPUS:0019494593
SN - 0047-6374
VL - 16
SP - 29
EP - 35
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 1
ER -