Active CMOS biochip for time-resolved fluorescence detection

George Patounakis; K. L. Shepard; R. Levicky

doi:10.1109/VLSIC.2005.1469336

Active CMOS biochip for time-resolved fluorescence detection

George Patounakis, K. L. Shepard, R. Levicky

Chemical and Biomolecular Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 10⁸/cm², has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.

Original language	English (US)
Pages	68-71
Number of pages	4
DOIs	https://doi.org/10.1109/VLSIC.2005.1469336
State	Published - 2005
Event	2005 Symposium on VLSI Circuits - Kyoto, Japan Duration: Jun 16 2005 → Jun 18 2005

Other

Other	2005 Symposium on VLSI Circuits
Country/Territory	Japan
City	Kyoto
Period	6/16/05 → 6/18/05

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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10.1109/VLSIC.2005.1469336

Cite this

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title = "Active CMOS biochip for time-resolved fluorescence detection",

abstract = "This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 108/cm2, has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.",

author = "George Patounakis and Shepard, {K. L.} and R. Levicky",

year = "2005",

doi = "10.1109/VLSIC.2005.1469336",

language = "English (US)",

pages = "68--71",

note = "2005 Symposium on VLSI Circuits ; Conference date: 16-06-2005 Through 18-06-2005",

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AU - Patounakis, George

AU - Shepard, K. L.

AU - Levicky, R.

PY - 2005

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AB - This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 108/cm2, has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.

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DO - 10.1109/VLSIC.2005.1469336

M3 - Paper

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SP - 68

EP - 71

T2 - 2005 Symposium on VLSI Circuits

Y2 - 16 June 2005 through 18 June 2005

ER -

Active CMOS biochip for time-resolved fluorescence detection

Abstract

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