Activity of Prefrontal Neurons Predict Future Choices during Gambling

Johannes Passecker, Nace Mikus, Hugo Malagon-Vina, Philip Anner, Jordane Dimidschstein, Gordon Fishell, Georg Dorffner, Thomas Klausberger

Research output: Contribution to journalArticle

Abstract

Passecker et al. show that specialized neurons in the prelimbic cortex of rats predict the next choice during the outcome evaluation in a gambling task, even for unlikely or uncertain decisions. Disrupting the prelimbic cortex led to excessive risk taking.

Original languageEnglish (US)
Pages (from-to)152-164.e7
JournalNeuron
Volume101
Issue number1
DOIs
StatePublished - Jan 2 2019

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Keywords

  • adaptive control
  • decision-making
  • gambling
  • negative feedback
  • outcome evaluation
  • prefrontal cortex
  • prelimbic cortex
  • risk

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Passecker, J., Mikus, N., Malagon-Vina, H., Anner, P., Dimidschstein, J., Fishell, G., Dorffner, G., & Klausberger, T. (2019). Activity of Prefrontal Neurons Predict Future Choices during Gambling. Neuron, 101(1), 152-164.e7. https://doi.org/10.1016/j.neuron.2018.10.050