Activity of Prefrontal Neurons Predict Future Choices during Gambling

Johannes Passecker; Nace Mikus; Hugo Malagon-Vina; Philip Anner; Jordane Dimidschstein; Gordon Fishell; Georg Dorffner; Thomas Klausberger

doi:10.1016/j.neuron.2018.10.050

Activity of Prefrontal Neurons Predict Future Choices during Gambling

Johannes Passecker, Nace Mikus, Hugo Malagon-Vina, Philip Anner, Jordane Dimidschstein, Gordon Fishell, Georg Dorffner, Thomas Klausberger

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Passecker et al. show that specialized neurons in the prelimbic cortex of rats predict the next choice during the outcome evaluation in a gambling task, even for unlikely or uncertain decisions. Disrupting the prelimbic cortex led to excessive risk taking.

Original language	English (US)
Pages (from-to)	152-164.e7
Journal	Neuron
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2018.10.050
State	Published - Jan 2 2019

Keywords

adaptive control
decision-making
gambling
negative feedback
outcome evaluation
prefrontal cortex
prelimbic cortex
risk

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2018.10.050

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abstract = "Passecker et al. show that specialized neurons in the prelimbic cortex of rats predict the next choice during the outcome evaluation in a gambling task, even for unlikely or uncertain decisions. Disrupting the prelimbic cortex led to excessive risk taking.",

keywords = "adaptive control, decision-making, gambling, negative feedback, outcome evaluation, prefrontal cortex, prelimbic cortex, risk",

author = "Johannes Passecker and Nace Mikus and Hugo Malagon-Vina and Philip Anner and Jordane Dimidschstein and Gordon Fishell and Georg Dorffner and Thomas Klausberger",

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AU - Dimidschstein, Jordane

AU - Fishell, Gordon

AU - Dorffner, Georg

AU - Klausberger, Thomas

PY - 2019/1/2

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KW - negative feedback

KW - outcome evaluation

KW - prefrontal cortex

KW - prelimbic cortex

KW - risk

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Activity of Prefrontal Neurons Predict Future Choices during Gambling

Abstract

Keywords

ASJC Scopus subject areas

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