Acute sleep disruption does not diminish pulsatile growth hormone secretion in pubertal children

Madison E Calvert, Samantha A Molsberry, Tairmae Kangarloo, Md Rafiul Amin, Valentina Genty, Rose T. Faghih, Elizabeth B. Klerman, Natalie D Shaw

    Research output: Contribution to journalArticlepeer-review

    Abstract


    Study Objectives
    In children, growth hormone (GH) pulses occur after sleep onset in association with slow wave sleep (SWS). There have been no studies in children to quantify the effect of disrupted sleep on GH secretion. This study aimed to investigate the effect of acute sleep disruption on GH secretion in pubertal children.

    Methods
    Fourteen healthy subjects (aged 11.3-14.1 yrs) were randomized to two overnight polysomnographic studies, one with and one without SWS disruption via auditory stimuli, with frequent blood sampling to measure GH.

    Results
    Auditory stimuli delivered during the disrupted sleep night caused a 40.0 ± 7.8% decrease in SWS. On SWS disrupted sleep nights compared to the undisrupted night, the rate of GH pulses during N2 sleep was significantly lower than during SWS (IRR = 0.56, 95% CI: 0.32-0.97) but there were no differences in SWS and the other sleep stages. SWS sleep disruption had no effect on GH pulse amplitude and frequency or basal GH secretion.

    Conclusion
    In pubertal children, GH pulses were temporally associated with episodes of SWS. Acute disruption of sleep via auditory tones during SWS did not alter GH secretion. These results indicate that SWS may not be a direct stimulus of GH secretion.
    Original languageEnglish (US)
    JournalJournal of the Endocrine Society
    DOIs
    StatePublished - Sep 16 2022

    Fingerprint

    Dive into the research topics of 'Acute sleep disruption does not diminish pulsatile growth hormone secretion in pubertal children'. Together they form a unique fingerprint.

    Cite this