Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Victor M. Luna; Christoph Anacker; Nesha S. Burghardt; Hameda Khandaker; Valentine Andreu; Amira Millette; Paige Leary; Rebecca Ravenelle; Jessica C. Jimenez; Alessia Mastrodonato; Christine A. Denny; Andre A. Fenton; Helen E. Scharfman; Rene Hen

doi:10.1126/science.aat8789

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Victor M. Luna, Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, Rebecca Ravenelle, Jessica C. Jimenez, Alessia Mastrodonato, Christine A. Denny, Andre A. Fenton, Helen E. Scharfman, Rene Hen

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

Original language	English (US)
Pages (from-to)	578-583
Number of pages	6
Journal	Science
Volume	364
Issue number	6440
DOIs	https://doi.org/10.1126/science.aat8789
State	Published - 2019

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Luna, V. M., Anacker, C., Burghardt, N. S., Khandaker, H., Andreu, V., Millette, A., Leary, P., Ravenelle, R., Jimenez, J. C., Mastrodonato, A., Denny, C. A., Fenton, A. A., Scharfman, H. E., & Hen, R. (2019). Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science, 364(6440), 578-583. https://doi.org/10.1126/science.aat8789

@article{93fd4f24514842eca574a3f9dba1b64a,

title = "Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus",

abstract = "Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.",

author = "Luna, {Victor M.} and Christoph Anacker and Burghardt, {Nesha S.} and Hameda Khandaker and Valentine Andreu and Amira Millette and Paige Leary and Rebecca Ravenelle and Jimenez, {Jessica C.} and Alessia Mastrodonato and Denny, {Christine A.} and Fenton, {Andre A.} and Scharfman, {Helen E.} and Rene Hen",

note = "Funding Information: This work was supported by National Institutes of Health grants to V.M.L. (K01 AG054765), C.A. (K99 MH108719), N.S.B. (G12MD007599), C.A.D. (DP5 OD017908), A.A.F. (R01 AG043688), H.E.S. (R01 NS081203), and R.H. (R37 MH068542, R01 MH083862, R01 AG043688, R01 NS081203, and T32 MH01574). A.Ma. was supported by a Rotary Global Grant (GG1864162) and a Sackler award. C.A.D. was supported by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (P&S Investigator). C.A.D. and R.H. were supported by NYSTEM (C029157). R.H. was also supported by the Hope for Depression Research Foundation (RGA-13-003). Publisher Copyright: {\textcopyright} 2019 American Association for the Advancement of Science. All rights reserved.",

year = "2019",

doi = "10.1126/science.aat8789",

language = "English (US)",

volume = "364",

pages = "578--583",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6440",

}

TY - JOUR

T1 - Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

AU - Luna, Victor M.

AU - Anacker, Christoph

AU - Burghardt, Nesha S.

AU - Khandaker, Hameda

AU - Andreu, Valentine

AU - Millette, Amira

AU - Leary, Paige

AU - Ravenelle, Rebecca

AU - Jimenez, Jessica C.

AU - Mastrodonato, Alessia

AU - Denny, Christine A.

AU - Fenton, Andre A.

AU - Scharfman, Helen E.

AU - Hen, Rene

N1 - Funding Information: This work was supported by National Institutes of Health grants to V.M.L. (K01 AG054765), C.A. (K99 MH108719), N.S.B. (G12MD007599), C.A.D. (DP5 OD017908), A.A.F. (R01 AG043688), H.E.S. (R01 NS081203), and R.H. (R37 MH068542, R01 MH083862, R01 AG043688, R01 NS081203, and T32 MH01574). A.Ma. was supported by a Rotary Global Grant (GG1864162) and a Sackler award. C.A.D. was supported by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (P&S Investigator). C.A.D. and R.H. were supported by NYSTEM (C029157). R.H. was also supported by the Hope for Depression Research Foundation (RGA-13-003). Publisher Copyright: © 2019 American Association for the Advancement of Science. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

AB - Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

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U2 - 10.1126/science.aat8789

DO - 10.1126/science.aat8789

M3 - Article

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AN - SCOPUS:85065861281

SN - 0036-8075

VL - 364

SP - 578

EP - 583

JO - Science

JF - Science

IS - 6440

ER -

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

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