Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Victor M. Luna, Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, Rebecca Ravenelle, Jessica C. Jimenez, Alessia Mastrodonato, Christine A. Denny, Andre A. Fenton, Helen E. Scharfman, Rene Hen

Research output: Contribution to journalArticlepeer-review


Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

Original languageEnglish (US)
Pages (from-to)578-583
Number of pages6
Issue number6440
StatePublished - 2019

ASJC Scopus subject areas

  • General


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