Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Minouk J. Schoemaker, Hazel B. Nichols, Lauren B. Wright, Mark N. Brook, Michael E. Jones, Katie M. O'Brien, Hans Olov Adami, Laura Baglietto, Leslie Bernstein, Kimberly A. Bertrand, Marie Christine Boutron-Ruault, Yu Chen, Avonne E. Connor, Laure Dossus, A. Heather Eliassen, Graham G. Giles, Inger T. Gram, Susan E. Hankinson, Rudolf Kaaks, Timothy J. KeyVictoria A. Kirsh, Cari M. Kitahara, Susanna C. Larsson, Martha Linet, Huiyan Ma, Roger L. Milne, Kotaro Ozasa, Julie R. Palmer, Elio Riboli, Thomas E. Rohan, Carlotta Sacerdote, Atsuko Sadakane, Malin Sund, Rulla M. Tamimi, Antonia Trichopoulou, Giske Ursin, Kala Visvanathan, Elisabete Weiderpass, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Dale P. Sandler, Anthony J. Swerdlow

Research output: Contribution to journalArticlepeer-review


Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

Original languageEnglish (US)
Pages (from-to)1306-1314
Number of pages9
JournalInternational Journal of Cancer
Issue number5
StatePublished - Sep 1 2020


  • body weight changes
  • breast neoplasms
  • cohort studies
  • premenopause
  • risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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