TY - JOUR
T1 - Advanced imaging for glaucoma study
T2 - Design, baseline characteristics, and inter-site comparison
AU - Le, Phuc V.
AU - Zhang, Xinbo
AU - Francis, Brian A.
AU - Varma, Rohit
AU - Greenfield, David S.
AU - Schuman, Joel S.
AU - Loewen, Nils
AU - Huang, David
N1 - Funding Information:
Dr Chopra received honoraria from Optovue, Inc (Fremont, California, USA). Dr Greenfield receives research support from Optovue Inc (Fremont, California, USA), Carl Zeiss Meditec, Inc (Dublin, California, USA), and Heidelberg Engineering (Heidelberg, Germany). Drs Huang and Schuman receive royalties for an optical coherence tomography patent owned and licensed by the Massachusetts Institute of Technology and Massachusetts Eye & Ear Infirmary to Carl Zeiss Meditec, Inc (Dublin, California, USA). Drs Huang, Tan, and Wang have a financial interest in Optovue, Inc (Fremont, California, USA), a company involved in the study. The nature of this financial interest and the design of the study have been reviewed by a committee at Oregon Health & Science University and a plan has been put into place to ensure this research study is not affected by the financial interest. Dr Sadda has served as a consultant for Optos plc (Dunfermline, Scotland, UK), and Carl Zeiss Meditec, Inc (Dublin, California, USA) and has received research support from Optovue Inc (Fremont, California, USA), Optos plc (Dunfermline, Scotland, UK), and Carl Zeiss Meditec, Inc (Dublin, California, USA). Dr Varma received research grants, honoraria, and/or travel support from Carl Zeiss Meditec, Inc (Dublin, California, USA), Heidelberg Engineering (Heidelberg, Germany), and Optovue Inc (Fremont, California, USA).
Funding Information:
Financial disclosures: Dr Greenfield receives research support from Optovue Inc (Fremont, California, USA), Carl Zeiss Meditec, Inc (Dublin, California, USA), and Heidelberg Engineering (Heidelberg, Germany). Drs Huang and Schuman receive royalties for an optical coherence tomography patent owned and licensed by the Massachusetts Institute of Technology and Massachusetts Eye & Ear Infirmary to Carl Zeiss Meditec, Inc (Dublin, California, USA). Dr Huang has a significant financial interest in Optovue, Inc (Fremont, California, USA), a company that may have a commercial interest in the results of this research and technology. These potential conflicts of interest have been reviewed and managed by Oregon Health & Science University. Dr Varma has received research grants, honoraria, and/or travel support from Carl Zeiss Meditec Inc (Dublin, California, USA) Heidelberg Engineering (Heidelberg, Germany), and Optovue, Inc (Fremont, California, USA).
Funding Information:
Funding support: Supported by NIH grants: EY013516 , P30-EY008098 , K08EY022737 ; Eye and Ear Foundation (Pittsburgh, Pennsylvania, USA); Research to Prevent Blindness (New York, New York, USA).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation <2%), followed by time-domain OCT (coefficient of variation 2%-2.9%), scanning laser polarimetry (coefficient of variation 2.6%-4.5%), and confocal scanning laser ophthalmoscopy rim area (coefficient of variation 4.2%-7.6%). A mixed-effects model showed that the differences between sites was less than 25 percent of the variation within groups and less than the differences between the normal and glaucoma suspect/preperimetric glaucoma group. Conclusions Site-to-site variation was smaller than both the variation within groups and the changes attributable to glaucoma. Therefore pooling of participants between sites is appropriate.
AB - Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation <2%), followed by time-domain OCT (coefficient of variation 2%-2.9%), scanning laser polarimetry (coefficient of variation 2.6%-4.5%), and confocal scanning laser ophthalmoscopy rim area (coefficient of variation 4.2%-7.6%). A mixed-effects model showed that the differences between sites was less than 25 percent of the variation within groups and less than the differences between the normal and glaucoma suspect/preperimetric glaucoma group. Conclusions Site-to-site variation was smaller than both the variation within groups and the changes attributable to glaucoma. Therefore pooling of participants between sites is appropriate.
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U2 - 10.1016/j.ajo.2014.11.010
DO - 10.1016/j.ajo.2014.11.010
M3 - Article
C2 - 25447111
AN - SCOPUS:84919807850
SN - 0002-9394
VL - 159
SP - 393-403.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -