Advanced scanning methods with tracking optical coherence tomography

Daniel X. Hammer, R. Daniel Ferguson, Nicusor V. Iftimia, Teoman Ustun, Gadi Wollstein, Hiroshi Ishikawa, Michelle L. Gabriele, William D. Dilworth, Larry Kagemann, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    An upgraded optical coherence tomography system with integrated retinal tracker (TOCT) was developed. The upgraded system uses improved components to extend the tracking bandwidth, fully integrates the tracking hardware into the optical head of the clinical OCT system, and operates from a single software platform. The system was able to achieve transverse scan registration with sub-pixel accuracy (∼10 μm). We demonstrate several advanced scan sequences with the TOCT, including composite scans averaged (co-added) from multiple B-scans taken consecutively and several hours apart, en face images collected by summing the A-scans of circular, line, and raster scans, and three-dimensional (3D) retinal maps of the fovea and optic disc. The new system achieves highly accurate OCT scan registration yielding composite images with significantly improved spatial resolution, increased signal-to-noise ratio, and reduced speckle while maintaining well-defined boundaries and sharp fine structure compared to single scans. Precise re-registration of multiple scans over separate imaging sessions demonstrates TOCT utility for longitudinal studies. En face images and 3D data cubes generated from these data reveal high fidelity image registration with tracking, despite scan durations of more than one minute.

    Original languageEnglish (US)
    Pages (from-to)7937-7947
    Number of pages11
    JournalOptics Express
    Volume13
    Issue number20
    DOIs
    StatePublished - Oct 3 2005

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics

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  • Cite this

    Hammer, D. X., Ferguson, R. D., Iftimia, N. V., Ustun, T., Wollstein, G., Ishikawa, H., Gabriele, M. L., Dilworth, W. D., Kagemann, L., & Schuman, J. S. (2005). Advanced scanning methods with tracking optical coherence tomography. Optics Express, 13(20), 7937-7947. https://doi.org/10.1364/OPEX.13.007937