TY - JOUR
T1 - Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer
AU - Yaman, Ismail
AU - Çobanoğlu, Didem Ağaç
AU - Xie, Tongxin
AU - Ye, Yi
AU - Amit, Moran
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/11
Y1 - 2022/11
N2 - Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions with the immune system in the tumor microenvironment may lead to the development of new cancer treatments. This review discusses the effects of nerve cells, immune cells, and cancer cells have on each other that regulate neurogenesis, cancer progression, and dissemination.
AB - Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions with the immune system in the tumor microenvironment may lead to the development of new cancer treatments. This review discusses the effects of nerve cells, immune cells, and cancer cells have on each other that regulate neurogenesis, cancer progression, and dissemination.
KW - Cancer
KW - Neuroimmune axis
KW - Parasympathetic nervous system
KW - Sympathetic nervous system
KW - Tumor microenvironment
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U2 - 10.1016/j.pharmthera.2022.108199
DO - 10.1016/j.pharmthera.2022.108199
M3 - Review article
C2 - 35490859
AN - SCOPUS:85129937361
SN - 0163-7258
VL - 239
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 108199
ER -