Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts

Nadine Pernodet, Xiaohua Fang, Yuan Sun, Asya Bakhtina, Aditi Ramakrishnan, Jonathan Sokolov, Abraham Ulman, Miriam Rafailovich

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoscale engineering is one of the most dynamically growing areas at the interface between electronics, physics, biology, and medicine. As there are no safety regulations yet, concerns about future health problems are rising. We investigated the effects of citrate/gold nanoparticles at different concentrations and exposure times on human dermal fibroblasts. We found that, as a result of intracellular nanoparticle presence, actin stress fibers disappeared, thereby inducing major adverse effects on cell viability. Thus, properties such as cell spreading and adhesion, cell growth, and protein synthesis to form the extracellular matrix were altered dramatically. These results suggest that the internal cell activities have been damaged.

Original languageEnglish (US)
Pages (from-to)766-773
Number of pages8
JournalSmall
Volume2
Issue number6
DOIs
StatePublished - Jun 2006

Keywords

  • Actin
  • Cell adhesion
  • Cell growth
  • Gold, nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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