TY - GEN
T1 - AFM compatible microfluidic platform for mechanical characterization of prostate circulating tumor cells
AU - Deliorman, Muhammedin
AU - Alnemari, Roaa
AU - Janahi, Farhad K.
AU - Qasaimeh, Mohammad A.
N1 - Publisher Copyright:
© 17CBMS-0001.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - We have developed a microfluidic platform that is compatible with atomic force microscope (AFM) to isolate and quantitatively measure adhesive and nanomechanical properties of intact prostate circulating tumor cells (CTCs). A robust linker chemistry was used to efficiently capture CTCs through high density of active antibodies, with minimal nonspecific binding of other blood cells. The platform was proven to be successful in nanomechanically characterizing intact single cancer cells.
AB - We have developed a microfluidic platform that is compatible with atomic force microscope (AFM) to isolate and quantitatively measure adhesive and nanomechanical properties of intact prostate circulating tumor cells (CTCs). A robust linker chemistry was used to efficiently capture CTCs through high density of active antibodies, with minimal nonspecific binding of other blood cells. The platform was proven to be successful in nanomechanically characterizing intact single cancer cells.
KW - AFM
KW - Circulating Tumor Cells
KW - Microfluidic
UR - http://www.scopus.com/inward/record.url?scp=85066602467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066602467&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85066602467
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 860
EP - 861
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -