AFM compatible microfluidic platform for mechanical characterization of prostate circulating tumor cells

Muhammedin Deliorman, Roaa Alnemari, Farhad K. Janahi, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a microfluidic platform that is compatible with atomic force microscope (AFM) to isolate and quantitatively measure adhesive and nanomechanical properties of intact prostate circulating tumor cells (CTCs). A robust linker chemistry was used to efficiently capture CTCs through high density of active antibodies, with minimal nonspecific binding of other blood cells. The platform was proven to be successful in nanomechanically characterizing intact single cancer cells.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages860-861
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

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Keywords

  • AFM
  • Circulating Tumor Cells
  • Microfluidic

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Deliorman, M., Alnemari, R., Janahi, F. K., & Qasaimeh, M. A. (2020). AFM compatible microfluidic platform for mechanical characterization of prostate circulating tumor cells. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 860-861). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.