TY - JOUR
T1 - Age-related changes in EGF and protease in submandibular glands of C57BL/6J Mice
AU - Gresik, Edward W.
AU - Brennan, Michael
AU - Azmitia, Efrain
N1 - Funding Information:
!Supported by research grants BNS-7906474 from the National Science Foundation to E. Azmitia. AM-DE 19753 from the National Institutes of Health'to T. Barka. and AG 00760 from the National Institute on Aging to D. Quartermain. E. Azmitia is the recipient of an Irma T. Hirschl Career Development Award. We extend our thanks to Dr. D. Quartermain for providing us with the mice used in these studies, to Ms. H. van der Noen for carrying out the radioimmunoassays for EGF, to Mr. Patrick Gannon for his excellent photographic services, and to Dr. Smith for prfor- ming the statistical analyses, and to Dr. T. Barka for his critical reading of the manuscript. Address requests for reprints to E.W.G raik. Dept. Of Anatomy, Mount Sinai School of Medicine, New York. N.Y. 10029. *From the Department of Anatomy, Mount Sinai School of Medicine of the City University of New York, 100th Street and Fifth Avenue, New York, NY 10029, U.S.A. 'From the Department of Behavioral Neurology, School of Medicine, New York University, New York, U.S.A.
PY - 1982
Y1 - 1982
N2 - The submandibular glands of male C57BL/6J mice were studied cytologically and chemically at the following ages (months): 1-1.5, 6-8, 12-13, 28-32. The relative proportion of granular convoluted tubules (GCT), as well as the size and content of secretion granules of GCT cells, progressively increased throughout the first year of life. Correspondingly, the concentration within the glands of two GCT cell products, epidermal growth factor (EGF) and protease, also steadily increased. In senescent glands, GCTs formed relatively less of the gland parenchyma and were composed of shorter cells with reduced amounts of secretory granules. The concentration of EGF was reduced to 17% of its peak value at one year, while protease activity declined to 50% of its peak value. These morphologic and chemical Findings imply a functional impairment in submandibular glands of the mouse with senescence.
AB - The submandibular glands of male C57BL/6J mice were studied cytologically and chemically at the following ages (months): 1-1.5, 6-8, 12-13, 28-32. The relative proportion of granular convoluted tubules (GCT), as well as the size and content of secretion granules of GCT cells, progressively increased throughout the first year of life. Correspondingly, the concentration within the glands of two GCT cell products, epidermal growth factor (EGF) and protease, also steadily increased. In senescent glands, GCTs formed relatively less of the gland parenchyma and were composed of shorter cells with reduced amounts of secretory granules. The concentration of EGF was reduced to 17% of its peak value at one year, while protease activity declined to 50% of its peak value. These morphologic and chemical Findings imply a functional impairment in submandibular glands of the mouse with senescence.
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U2 - 10.1080/03610738208258402
DO - 10.1080/03610738208258402
M3 - Article
C2 - 6751832
AN - SCOPUS:0019988612
SN - 0361-073X
VL - 8
SP - 87
EP - 90
JO - Experimental Aging Research
JF - Experimental Aging Research
IS - 2
ER -