Agent-based modeling: Case study in cleavage furrow models

Alex Mogilner, Angelika Manhart

Research output: Contribution to journalReview articlepeer-review


The number of studies in cell biology in which quantitative models accompany experiments has been growing steadily. Roughly, mathematical and computational techniques of these models can be classified as "differential equation based" (DE) or "agent based" (AB). Recently AB models have started to outnumber DE models, but understanding of AB philosophy and methodology is much less widespread than familiarity with DE techniques. Here we use the history of modeling a fundamental biological problem-positioning of the cleavage furrow in dividing cells-to explain how and why DE and AB models are used. We discuss differences, advantages, and shortcomings of these two approaches.

Original languageEnglish (US)
Pages (from-to)3379-3384
Number of pages6
JournalMolecular biology of the cell
Issue number22
StatePublished - Nov 7 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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