Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Peishen Zhao, Meritxell Canals, Jane E. Murphy, Diana Klingler, Emily M. Eriksson, Juan Carlos Pelayo, Markus Hardt, Nigel W. Bunnett, Daniel P. Poole

Research output: Contribution to journalArticle

Abstract

Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.

Original languageEnglish (US)
Pages (from-to)25689-25700
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Zhao, P., Canals, M., Murphy, J. E., Klingler, D., Eriksson, E. M., Pelayo, J. C., Hardt, M., Bunnett, N. W., & Poole, D. P. (2013). Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons. Journal of Biological Chemistry, 288(36), 25689-25700. https://doi.org/10.1074/jbc.M113.496414