Abstract
Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.
Original language | English (US) |
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Pages (from-to) | 25689-25700 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 36 |
DOIs | |
State | Published - Sep 6 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology