Abstract
The effects of proteinase-activated receptor 2 (PAR2) agonists on the electrical properties of intact guinea pig ileal myenteric neurons were measured with intracellular microelectrodes. Approximately 52% of AH neurons and 41% of S neurons responded to pressure ejection of SLIGRL-NH2 or trypsin with a prolonged depolarization that was often accompanied by increased excitability. When added to the bathing solution, trypsin caused a concentration-dependent depolarization of responding neurons with an estimated EC50 value of 87 nM. Collectively, these novel observations indicate that PAR2 excites a proportion of myenteric neurons, which may contribute to dysmotility during intestinal inflammation.
Original language | English (US) |
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Pages (from-to) | 311-314 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 431 |
Issue number | 3 |
DOIs | |
State | Published - Nov 23 2001 |
Keywords
- Electrophysiology
- Euteric nervous system
- Neuroimmune interaction
- Thrombin receptor
- Trypsin
ASJC Scopus subject areas
- Pharmacology