Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures

R. Ghosh; W. J. Gauderman; H. Minor; H. A. Youn; F. Lurmann; K. R. Cromar; L. Chatzi; B. Belcher; C. R. Fielding; R. McConnell

doi:10.1111/ijpo.12210

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures

R. Ghosh, W. J. Gauderman, H. Minor, H. A. Youn, F. Lurmann, K. R. Cromar, L. Chatzi, B. Belcher, C. R. Fielding, R. McConnell

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. Objectives: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. Methods: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA_1c) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB). Residential distances to major roads and the average two-year follow-up exposure to particulate matter <2.5 μm (PM_2.5), nitrogen dioxide (NO₂) and ozone were estimated. Associations of exposure with change in outcome and with attained outcome two years post-surgery were examined. Results: Major-roadway proximity was associated with reduced EWL and less improvement in lipid profile and ALP after surgery. NO₂ was associated with less improvement in HbA_1c and lower attained HDL levels and change in triglycerides over two years post-surgery. PM_2.5 was associated with reduced EWL and reduced beneficial change or attained levels for all outcomes except HbA_1c. Conclusions: Near-roadway, PM_2.5 and NO₂ exposures at levels common in developed countries were associated with reduced EWL and metabolic benefits of LAGB. This novel approach provides a model for investigating metabolic effects of other exposures.

Original language	English (US)
Pages (from-to)	312-320
Number of pages	9
Journal	Pediatric Obesity
Volume	13
Issue number	5
DOIs	https://doi.org/10.1111/ijpo.12210
State	Published - May 2018

Keywords

Air pollution
bariatric surgery
lipids
metabolic syndrome
obesity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Health Policy
Nutrition and Dietetics
Public Health, Environmental and Occupational Health

Access to Document

10.1111/ijpo.12210

Cite this

@article{6395eec465ba4528a889882b2dbfc790,

title = "Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures",

abstract = "Background: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. Objectives: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. Methods: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA1c) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB). Residential distances to major roads and the average two-year follow-up exposure to particulate matter <2.5 μm (PM2.5), nitrogen dioxide (NO2) and ozone were estimated. Associations of exposure with change in outcome and with attained outcome two years post-surgery were examined. Results: Major-roadway proximity was associated with reduced EWL and less improvement in lipid profile and ALP after surgery. NO2 was associated with less improvement in HbA1c and lower attained HDL levels and change in triglycerides over two years post-surgery. PM2.5 was associated with reduced EWL and reduced beneficial change or attained levels for all outcomes except HbA1c. Conclusions: Near-roadway, PM2.5 and NO2 exposures at levels common in developed countries were associated with reduced EWL and metabolic benefits of LAGB. This novel approach provides a model for investigating metabolic effects of other exposures.",

keywords = "Air pollution, bariatric surgery, lipids, metabolic syndrome, obesity",

author = "R. Ghosh and Gauderman, {W. J.} and H. Minor and Youn, {H. A.} and F. Lurmann and Cromar, {K. R.} and L. Chatzi and B. Belcher and Fielding, {C. R.} and R. McConnell",

note = "Funding Information: Funding was provided by the National Institutes of Health (grants #P01ES022845, R21ES024707 and P01ES009581), and the U.S. Environmental Protection Agency (grant #RD083544101). Support was also provided by funds from an air quality violation settlement agreement between the South Coast Air Quality Management District, a California state regulatory agency, and BP. Publisher Copyright: {\textcopyright} 2017 World Obesity Federation",

year = "2018",

month = may,

doi = "10.1111/ijpo.12210",

language = "English (US)",

volume = "13",

pages = "312--320",

journal = "Pediatric Obesity",

issn = "2047-6302",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Air pollution, weight loss and metabolic benefits of bariatric surgery

T2 - a potential model for study of metabolic effects of environmental exposures

AU - Ghosh, R.

AU - Gauderman, W. J.

AU - Minor, H.

AU - Youn, H. A.

AU - Lurmann, F.

AU - Cromar, K. R.

AU - Chatzi, L.

AU - Belcher, B.

AU - Fielding, C. R.

AU - McConnell, R.

N1 - Funding Information: Funding was provided by the National Institutes of Health (grants #P01ES022845, R21ES024707 and P01ES009581), and the U.S. Environmental Protection Agency (grant #RD083544101). Support was also provided by funds from an air quality violation settlement agreement between the South Coast Air Quality Management District, a California state regulatory agency, and BP. Publisher Copyright: © 2017 World Obesity Federation

PY - 2018/5

Y1 - 2018/5

N2 - Background: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. Objectives: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. Methods: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA1c) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB). Residential distances to major roads and the average two-year follow-up exposure to particulate matter <2.5 μm (PM2.5), nitrogen dioxide (NO2) and ozone were estimated. Associations of exposure with change in outcome and with attained outcome two years post-surgery were examined. Results: Major-roadway proximity was associated with reduced EWL and less improvement in lipid profile and ALP after surgery. NO2 was associated with less improvement in HbA1c and lower attained HDL levels and change in triglycerides over two years post-surgery. PM2.5 was associated with reduced EWL and reduced beneficial change or attained levels for all outcomes except HbA1c. Conclusions: Near-roadway, PM2.5 and NO2 exposures at levels common in developed countries were associated with reduced EWL and metabolic benefits of LAGB. This novel approach provides a model for investigating metabolic effects of other exposures.

AB - Background: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. Objectives: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. Methods: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA1c) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB). Residential distances to major roads and the average two-year follow-up exposure to particulate matter <2.5 μm (PM2.5), nitrogen dioxide (NO2) and ozone were estimated. Associations of exposure with change in outcome and with attained outcome two years post-surgery were examined. Results: Major-roadway proximity was associated with reduced EWL and less improvement in lipid profile and ALP after surgery. NO2 was associated with less improvement in HbA1c and lower attained HDL levels and change in triglycerides over two years post-surgery. PM2.5 was associated with reduced EWL and reduced beneficial change or attained levels for all outcomes except HbA1c. Conclusions: Near-roadway, PM2.5 and NO2 exposures at levels common in developed countries were associated with reduced EWL and metabolic benefits of LAGB. This novel approach provides a model for investigating metabolic effects of other exposures.

KW - Air pollution

KW - bariatric surgery

KW - lipids

KW - metabolic syndrome

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85018615583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018615583&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12210

DO - 10.1111/ijpo.12210

M3 - Article

C2 - 28429404

AN - SCOPUS:85018615583

SN - 2047-6302

VL - 13

SP - 312

EP - 320

JO - Pediatric Obesity

JF - Pediatric Obesity

IS - 5

ER -

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this