Alanine scanning combined with interaction entropy studying the differences of binding mechanism on HIV-1 and HIV-2 proteases with inhibitor

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Alanine Scanning 100%
• Binding Mechanism 100%
• Interaction Entropy 100%
• HIV-2 Protease 100%
• Binding Energy 66%
• Hotspot Residues 66%
• HIV-2 50%
• Protein-ligand 33%
• Entropy Method 33%
• Specific Binding 16%
• Amino Acids 16%
• Binding Affinity 16%
• Protease Inhibitors 16%
• Protein Residue 16%
• Dielectric Constant 16%
• Entropy Change 16%
• 2-complex 16%
• Quantitative Characterization 16%
• Enthalpy-entropy Compensation 16%
• HIV Inhibitors 16%
• HIV-1 Protease 16%
• Normal Mode Method 16%
• Protein-ligand Binding 16%
• Molecular Mechanics Generalized Born Surface Area (MM-GBSA) 16%
• Entropy Approach 16%
• Theoretical Guidance 16%
• Statistical Stability 16%

Biochemistry, Genetics and Molecular Biology

• Protease 100%
• Human Immunodeficiency Virus 100%
• Alanine 100%
• Human Immunodeficiency Virus 1 100%
• Protein Ligand 33%
• Enthalpy 11%
• Amino Acids 11%
• Protease Inhibitor 11%
• Molecular Mechanic 11%
• Binding Affinity 11%
• Quantitative Technique 11%
• Ligand Binding 11%
• Dielectric Constant 11%
• Surface Area 11%
• HIV-1 Protease 11%