Alkaline materials and regenerative endodontics: A review

Bill Kahler, Nadia Chugal, Louis M. Lin

Research output: Contribution to journalReview articlepeer-review


Periapical health is the primary goal of endodontic treatment in mature and immature teeth. In addition, the goals of treatment of immature teeth with arrested root development include root growth to length and maturation of the apex, as well as thickening of the canal wall. These goals are valid for immature teeth that have been subjected to trauma and dental caries or that are the result of developmental anomalies that expose the tooth to the risk of pulp necrosis and consequently result inthe cessation of root maturation. Regenerative endodontic procedures (REPs) have been described as a "paradigm shift" in the treatment of immature teeth with pulp necrosis and underdeveloped roots, as there is the potential for further root maturation and return of vitality. Treatment with REPs is advocated as the treatment of choice for immature teeth with pulp necrosis. REP protocols involve the use of alkaline biomaterials, primarily sodium hypochlorite, calcium hydroxide, mineral trioxide aggregates and Biodentine, and are the essential components of a successful treatment regimen.

Original languageEnglish (US)
Article number1389
Issue number12
StatePublished - Dec 5 2017


  • Alkaline materials
  • Calcium silicates
  • Disinfection
  • Immature root
  • Regenerative endodontics

ASJC Scopus subject areas

  • General Materials Science


Dive into the research topics of 'Alkaline materials and regenerative endodontics: A review'. Together they form a unique fingerprint.

Cite this