Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions

Janarthanan Jayawickramarajah; Debarati M. Tagore; Lun K. Tsou; Andrew D. Hamilton

doi:10.1002/anie.200701883

Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions

Janarthanan Jayawickramarajah, Debarati M. Tagore, Lun K. Tsou, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

All four one: The covalent attachment (A) of a porphyrin head group onto a guanine-rich oligonucleotide strand can enhance the self-assembly of DNA quadruplexes through porphyrin-based π-π interactions (B). Modulation of these allosteric interactions, by addition of a porphyrin-complexing cyclodextrin derivative, allows for a high degree of control over the formation and disassembly of the guanine quadruplexes (C and D). (Figure Presented).

Original language	English (US)
Pages (from-to)	7583-7586
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	40
DOIs	https://doi.org/10.1002/anie.200701883
State	Published - 2007

Keywords

Cyclodextrins
DNA structures
Porphyrinoids
Supramolecular chemistry
π interactions

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200701883

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abstract = "All four one: The covalent attachment (A) of a porphyrin head group onto a guanine-rich oligonucleotide strand can enhance the self-assembly of DNA quadruplexes through porphyrin-based π-π interactions (B). Modulation of these allosteric interactions, by addition of a porphyrin-complexing cyclodextrin derivative, allows for a high degree of control over the formation and disassembly of the guanine quadruplexes (C and D). (Figure Presented).",

keywords = "Cyclodextrins, DNA structures, Porphyrinoids, Supramolecular chemistry, π interactions",

author = "Janarthanan Jayawickramarajah and Tagore, {Debarati M.} and Tsou, {Lun K.} and Hamilton, {Andrew D.}",

year = "2007",

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AU - Tsou, Lun K.

AU - Hamilton, Andrew D.

PY - 2007

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AB - All four one: The covalent attachment (A) of a porphyrin head group onto a guanine-rich oligonucleotide strand can enhance the self-assembly of DNA quadruplexes through porphyrin-based π-π interactions (B). Modulation of these allosteric interactions, by addition of a porphyrin-complexing cyclodextrin derivative, allows for a high degree of control over the formation and disassembly of the guanine quadruplexes (C and D). (Figure Presented).

KW - Cyclodextrins

KW - DNA structures

KW - Porphyrinoids

KW - Supramolecular chemistry

KW - π interactions

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ER -

Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions

Abstract

Keywords

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