Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions

Janarthanan Jayawickramarajah, Debarati M. Tagore, Lun K. Tsou, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

All four one: The covalent attachment (A) of a porphyrin head group onto a guanine-rich oligonucleotide strand can enhance the self-assembly of DNA quadruplexes through porphyrin-based π-π interactions (B). Modulation of these allosteric interactions, by addition of a porphyrin-complexing cyclodextrin derivative, allows for a high degree of control over the formation and disassembly of the guanine quadruplexes (C and D). (Figure Presented).

Original languageEnglish (US)
Pages (from-to)7583-7586
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number40
DOIs
StatePublished - 2007

Keywords

  • Cyclodextrins
  • DNA structures
  • Porphyrinoids
  • Supramolecular chemistry
  • π interactions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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