We report the levels of hypoxanthine in rabbit skin granulation tissue, harvested at different postwound intervals and from various locations within the wounds. The effect of full-thickness autogenous skin grafts on hypoxanthine levels has also been examined. The levels of inosine, xanthine, adenosine 5′-monophosphate, and inosine 5′-monophosphate are reported as well. The correlation between the level of these compounds and the healing process suggests they may be useful indicators of the extent of tissue damage.
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