Altered activity patterns during development reduce neural tuning

Dan H. Sanes, Martha Constantine-Paton

Research output: Contribution to journalArticlepeer-review

Abstract

Neonatal mice were reared in an acoustic environment that repetitively entrained activity in a large proportion of primary auditory afferents during the period when the frequency tuning of auditory neurons normally develops. The tuning curves obtained from these mice were significantly broader than those of normally reared mice of the same age. This suggests that the normal frequency tuning of neurons was prevented or delayed by synchronizing the pattern of activity imposed on the auditory pathway.

Original languageEnglish (US)
Pages (from-to)1183-1185
Number of pages3
JournalScience
Volume221
Issue number4616
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • General

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