TY - JOUR
T1 - Altered histopathology in protein-deprived mice during sendai virus pneumonia
T2 - Evidence for delayed inflammatory response and recovery
AU - Peña-Cruz, Victor
AU - Bronson, Roderick T.
AU - Reiss, Carol S.
AU - McIntosh, Kenneth
N1 - Funding Information:
Grant support: National Institutes ofHealth (AI-I 8083, S07 RR-05526, P30 CA-065 16), the Elsa U. Pardee Foundation (to C.R.S.), the National Council of Science and Technology, Mexico (46445 to V.P.-C.), and the World Health Organization Programme for Vaccine Development (to K.M.).
PY - 1992/5
Y1 - 1992/5
N2 - The morphology of the lungs and airway during the course of respiratory infection caused by Sendai virus was examined in normal (20% protein diet) and malnourished (2% protein diet) BALB/c mice. Mortality in normal Sendai-infected mice was 0 compared with 71% in the infected malnourished group. Virus was isolated until day 6 in normally fed mice and until day 9 in the malnourished group. Pulmonary inflammation was largely mononuclear and began in the normally nourished animals on day 3, peaked at day 6, and reverted almost to normal by 30 days. In the malnourished group, inflammation was delayed by about 1 day and fell further behind during the first week. It peaked 10-13 days after infection and was still present with little resolution by day 30. These findings may have relevance to the high mortality of acute respiratory diseases in children of the developing world.
AB - The morphology of the lungs and airway during the course of respiratory infection caused by Sendai virus was examined in normal (20% protein diet) and malnourished (2% protein diet) BALB/c mice. Mortality in normal Sendai-infected mice was 0 compared with 71% in the infected malnourished group. Virus was isolated until day 6 in normally fed mice and until day 9 in the malnourished group. Pulmonary inflammation was largely mononuclear and began in the normally nourished animals on day 3, peaked at day 6, and reverted almost to normal by 30 days. In the malnourished group, inflammation was delayed by about 1 day and fell further behind during the first week. It peaked 10-13 days after infection and was still present with little resolution by day 30. These findings may have relevance to the high mortality of acute respiratory diseases in children of the developing world.
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U2 - 10.1093/infdis/165.5.846
DO - 10.1093/infdis/165.5.846
M3 - Article
C2 - 1314870
AN - SCOPUS:0026587082
VL - 165
SP - 846
EP - 851
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -